1. MHC Hammer reveals genetic and non-genetic HLA disruption in ...
Oct 2, 2024 · Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution.
Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific mutation and measurement of expression and repression (MHC Hammer). We identified extensive variability in HLA allelic expression and pervasive HLA alternative splicing in normal lung and breast tissue. In lung TRACERx and lung and breast TCGA cohorts, 61% of lung adenocarcinoma (LUAD), 76% of lung squamous cell carcinoma (LUSC) and 35% of estrogen receptor-positive (ER+) cancers harbored class I HLA transcriptional repression, while HLA tumor-enriched alternative splicing occurred in 31%, 11% and 15% of LUAD, LUSC and ER+ cancers. Consistent with the importance of HLA dysfunction in tumor evolution, in LUADs, HLA LOH was associated with metastasis and LUAD primary tumor regions seeding a metastasis had a lower effective neoantigen burden than non-seeding regions. These data highlight the extent and importance of HLA transcriptomic disruption, including repression and alternative splicing in cancer evolution. Major histocompatibility complex (MHC) loss of heterozygosity, allele-specific mutation and measurement of expression and repression (MHC Hammer) detects disruption to human leukocyte antigens due to mutations, loss of heterogeneity, altered gene expression or alternative splicing. Applied to lung and breast cancer datasets, the tool shows that these...
2. Exploiting Tumor Neoantigens to Target Cancer Evolution
In a study of 17 cancer types in the TCGA dataset, for example, increased levels of RNA editing were found in several cancers, including breast cancer, lung ...
Immunotherapeutic manipulation of the antitumor immune response offers an attractive strategy to target genomic instability in cancer. A subset of tumor-specific somatic mutations can be translated into immunogenic and HLA-bound epitopes called ...
3. Matters of Life & Dating (2007) - Turner Classic Movies - TCM
A woman tries to move on with her life, and enter the dating world after surviving breast cancer and a mastectomy ... Jason Cadieux · Yanna Mcintosh · Donna ...
A woman tries to move on with her life, and enter the dating world after surviving breast cancer and a mastectomy.
4. Research/Quality/Performance Improvement
Early-stage and hormone receptor–positive breast cancers may need additional genomic testing to determine which patients need chemotherapy in addition to ...
Find original research, groundbreaking studies, and publish your own manuscript on JONS, AONN+'s platform for peer-reviewed academic literature.
5. [PDF] Arizona Adult Protective Services Registry
Oct 26, 2016 · ... Jason. 3/31/1965. On or about September 19, 2023, ROGER JASON BARRICK (date of birth 03/31/1965) exploited a vulnerable adult by illegally or ...
6. [PDF] Distinct evolutionary patterns of tumor immune escape and elimination ...
May 15, 2024 · To validate our findings, we conducted a survival anal- ysis on breast cancer (BRCA) patients from The Cancer ... Jason T George and Herbert ...
7. cancer - Find a Doctor | Beaumont Health
Breast Surgery. Affiliations. Beaumont Hospital, Grosse Pointe. Request an ... 313-277-0400 · Jason K Shellnut, MD. Accepting New ...
cancer - Nationally recognized, Beaumont Health has nearly 5,000 doctors throughout the Metro Detroit area. Find a Beaumont specialist near you.
8. Optimal cancer evasion in a dynamic immune microenvironment ... - eLife
Apr 25, 2023 · Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles. Jason T George Is a ...
Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
9. November 2020 Vol 11, No 11
... Cadieux, PhD; Darcy R. Flora, PhD; David C. Fuehrer ... Nassau and Suffolk counties on Long Island account for over 1500 breast cancer diagnoses annually.
Find original research, groundbreaking studies, and publish your own manuscript on JONS, AONN+'s platform for peer-reviewed academic literature.
